Developing chemotherapeutics which disable the actin cytoskeleton of melanoma cells

Title: Developing chemotherapeutics which disable the actin cytoskeleton of melanoma cells
Creator: Stehn, J. R.; Haass, N. K.; Hardeman, E.; Winlaw, D.; Weninger, W.; Gunning, P.; Desouza, M.; Sequeira, V. B.; Treutlein, H.; Zeng, J.; Nascimento, P. R. B. B.; Butler, T.; McCluskey, Adam; Palmer, S.
Relation: 2011 International Melanoma Congress. Pigment Cell & Melanoma Research (Tampa, FL 9-13 November, 2011) p. 1058
Publisher Link: http://dx.doi.org/10.1111/j.1755-148X.2011.00909.x
Publisher: Wiley-Blackwell Publishing
Resource Type: conference paper
Date: 2011
Description: To treat aggressive cancers such as melanoma it is imperative that new chemotherapeutic targets and agents be developed. The actin cytoskeleton, due to its role in biological processes fundamental to cellular transformation, has always been a sought after chemotherapeutic target. However, despite many years of research, attempts to develop actin targeting drugs for chemotherapy remains unsuccessful due to their lack of specificity which ultimately causes unacceptable cardiac and respiratory toxicity.
Subject: aggressive; melanoma; cardiac; respiratory toxicity
Identifier: http://hdl.handle.net/1959.13/1036280
Identifier: uon:13243
Identifier: ISSN:1755-148X
Language: eng
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